Accuracy and appearance of the Isosurface is affected by the LOD and refinement level.
Lighting can be enabled or disabled using the "Lighting On" checkbox in the Isosurface Appearance. The lighting is determined by the settings of the first light source in the View tab. Generally the isosurface appearance is improved with lighting enabled.
Bit depth: By default the Bits Per Voxel is set to 16. The isosurface appearance is usually better when using 16 bits, however setting 8 bits can sometimes result in faster rendering.